(D-Trp12,Tyr34)-pTH (7-34) amide (bovine) ( ——— )

产品货号. M40375 CAS No. 118102-98-0

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Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

(D-Trp12,Tyr34)-pTH (7-34) amide (bovine)
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

(D-Trp12,Tyr34)-pTH (7-34) amide (bovine) 是一种有效的竞争性甲状旁腺激素 (PTH) 拮抗剂，在牛肾皮质膜中的 Ki 值为 69 nM。(D-Trp12,Tyr34)-pTH (7-34) amide (bovine) 可用于生长发育调节。
产品描述

(D-Trp12,Tyr34)-pTH (7-34) amide (bovine) is a potent and competitive antagonist of parathyroid hormone (PTH), with a Ki of 69 nM in bovine renal cortical membrane. (D-Trp12,Tyr34)-pTH (7-34) amide (bovine) can be used for growth and development regulation.
体外实验

(D-Trp12,Tyr34)-pTH (7-34) amide (1 mg/mL once, 0.1 mg/mL for 6 h; i.v.) has no significant effect on serum calcium levels in hypercalcemic athymic nude mice bearing a human squamous cell carcinoma of the lung.
体内实验

(D-Trp12,Tyr34)-pTH (7-34) amide (0.05-10 μM) causes a concentration-dependent inhibition of PTHrP or PTH-stimulated cAMP formation in opossum kidney (OK) cells.(D-Trp12,Tyr34)-pTH (7-34) amide (0.1-10 μM) attenuates inhibition of NapiT promoted by 1 nM of either PTHrP or PTH.
同义词

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通路

Others
靶点

Other Targets
受体

Ki: 69 nM (PTH)
研究领域

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适应症

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1. Goldma ME, et, al. A new highly potent parathyroid hormone antagonist: D-Trp12,Tyr34bPTH-(7-34)NH2. Endocrinology. 1988 Nov; 123(5): 2597-9.?

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